David Saperstein, MD

David Saperstein, MD

I have been taking care of patients with peripheral neuropathy for over 20 years. Unfortunately, rather often the previous care of their neuropathy has not been ideal. Often patients with neuropathy are not given much information about their condition and told not much can be done. Sometimes patients do not have neuropathy or they do not have the type with which they have been diagnosed. Some patients are treated when they should and others are treated with therapies that will not help their neuropathy.

In response, I have harnessed my experience in diagnosing, treating, and researching peripheral neuropathy to create the Neuropathy Institute at the Center for Complex Neurology. Here my team and I will employ state-of-the-art techniques to make the most accurate diagnosis and institute the most effective and creative treatments. Better answers. Better solutions.

What will happen at the Neuropathy Institute at the Center for Complex Neurology?

Dr. Saperstein will speak with you and examine you. He will also examine your previous test results. His experience will allow him to hone in what could be causing your problems. He will then decide what tests might be necessary.

Options include:

  • Nerve conduction and EMG testing
  • Nerve ultrasound
  • MRI scans
  • Nerve or skin biopsy
  • Immunologic testing
  • Genetic testing
  • Spinal tap
All necessary testing will be performed at or coordinated by the Institute.

After Dr. Saperstein has had a chance to personally review the results he will discuss your diagnosis as well as treatment options. When possible, the underlying cause of your neuropathy will be treated. Unfortunately, far too often the neuropathy cannot be corrected and treatment focusses on relieving or decreasing symptoms. If helpful, medications such as gabapentin or Lyrica will be used. However, the Institute also utilizes cutting edge neuromodulating therapy, such as the Calmare pain treatment therapy. This is a medication free treatment that can retrain the brain to no longer register neuropathy pain. Dr. Saperstein is the only Neurologist in the state of Arizona to offer this technology.

Treatments available at the Neuropathy Institute at the Center for Complex Neurology include:

Treatments available at the Neuropathy Institute include:

  • Intravenous immunoglobulin and other biology therapies
  • IVIG and other biologic therapies
  • Physical therapy
  • Calmare Pain Treatment (medication-free treatment for nerve pain)

Most neuropathy centers are not staffed by neurologists specialized in peripheral neuropathy.

Dr. Saperstein regularly teaches physicians about neuropathy throughout the US as well as internationally. Internationally known neuropathy specialist Dr. Saperstein.

  • Established track record of diagnosing and treating peripheral neuropathy.
  • Fellowship trained in neuromuscular medicine and clinical neurophysiology.
  • Board-certified in neuromuscular medicine
  • Board-certified in electrodiagnostic medicine
  • Trained in performance and interpretation of nerve biopsies
  • Personally interpreted over 50,000 biopsies of small nerve fibers


A unique pain therapy device
A technologically advanced solution for chronic pain management. This device has been shown to be highly effective in the treatment of chemotherapy induced peripheral neuropathy (CIPN), drug-resistant chronic neuropathic and cancer pain, having long-lasting effects — an important benefit for both patients and their physicians.


A unique pain therapy device
A technologically advanced solution for chronic pain management. This device has been shown to be highly effective in the treatment of chemotherapy induced peripheral neuropathy (CIPN), drug-resistant chronic neuropathic and cancer pain, having long-lasting effects — an important benefit for both patients and their physicians.


The Calmare® device is a U.S. FDA 510(k)-cleared and European CE mark-certified pain therapy medical device for the non-invasive treatment of chronic neuropathic and oncologic pain. Treatment using the Calmare device avoids the harmful, adverse side effects and addictive properties linked to narcotic pain killers.

The Calmare device has been used to successfully treat over 4,000 patients worldwide, where it has been shown to be effective in treating neuropathic and oncologic pain. Conditions treated include:

• Chemotherapy-induced peripheral neuropathy (CIPN)
• Phantom limb syndrome
• Post-surgical neuropathic pain
• Low back pain
• Reflex sympathetic dystrophy
• Sciatica
• Postherpetic neuralgia (PHN)
• Neck pain

The device, with a biophysical rather than a biochemical approach, uses a multi-processor able to simultaneously treat multiple pain areas by applying surface electrodes to the skin. The device creates and sends a no-pain signal which becomes the dominant signal received by the brain, thus overriding the pain signal and providing relief for the patient.

In honor of the technology’s Italian inventors, CTI chose to call this medical device “Calmare”. Translated from Italian, “calmare” means “to soothe or ease.” Treatment utilizing the Calmare device can ease the suffering that patients endure from debilitating pain.

Who It’s For

The Calmare® platform is highly effective in the treatment of pain and has long-lasting effects, an important benefit for both physicians and their patients. Clinical studies have shown that the technology successfully reduces pain in more than 80 percent of treated patients without the adverse side effects commonly associated with drugs, therefore providing patients with a markedly improved quality of life.


  • Chemotherapy-induced Peripheral Neuropathy (CIPN)
  • Chronic Cancer Pain
  • Failed Back Surgery Syndrome (FBSS)
  • Sciatic and Lumbar Pain
  • Phantom Limb Syndrome
  • Postherpetic Neuralgia (PHN)
  • Post-surgical Neuropathic Pain
  • Brachial Plexus Neuropathy
  • Low Back Pain (LBP)
  • Chronic Neuropathic Pai


Due to the manner in which Calmare Pain Therapy Treatment operates, the following should be considered as possible exclusions:

  • Pacemaker or automatic defibrillator
  • Aneurysm clip, vena cava clips, or skull plates (metal implants for orthopedic repair, e.g. pins, plates, joint replacements are allowed)
  • Pregnant and/or breastfeeding
  • Prior celiac plexus block, or other neurolytic pain control treatment, within 4 weeks
  • Wounds or skin irritation in areas where the electrodes are required to be placed
  • History of, or have been treated for myocardial infarction or ischemic heart disease with the past six months
  • Severe arrhythmia or any form of equivalent heart disease
  • Implanted drug delivery system
  • Active withdrawal from drugs and/or alcohol
  • Previous intolerance to transcutaneous electronic nerve stimulation
  • Latex allergies


  • Because this device is capable of delivering a charge per pulse of 25 micro coulombs or greater, you should not place electrodes in a trans-thoracic position (may cause cardiac arrhythmia)
  • You are prone to skin irritation (isolated cases have occurred)
  • You have a implanted pain stimulator (operating or nonoperational) in which the proposed treatment is in the area of the implanted device (electrical current to area may interfere with the operation of the implanted device)
  • You are connected to other electronic monitoring equipment (ECG monitor) – may not operate properly with the medical device is in use

How It Works

The Calmare® device uses a biophysical rather than a biochemical approach. A ‘no-pain’ message is transmitted to the nerve via disposable surface electrodes applied to the skin in the region of the patient’s pain. The perception of pain is cancelled when the no-pain message replaces that of pain, by using the same pathway through the surface electrodes in a non-invasive way. Regardless of intensity, a patient’s pain can often be completely removed for immediate relief.

Maximum benefit is achieved through follow-up treatments. The patient may be able to go for extended periods of time between subsequent treatments while experiencing significant pain control and relief. The period of time between treatments depends on the underlying cause and severity of the pain in addition to other factors.


  • Non-invasive
  • Painless
  • Immediate pain relief
  • Ongoing pain control
  • No adverse side effects of opioids and other drugs


  • 5 independent channels
  • Disposable surface electrodes
  • Independent output intensity on each channel
  • Dynamic synthesizer processor
  • Maximum output current: 5mA RMS